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Research studies have demonstrated reductions in body weight gain and increased lipolytic activity in adipose tissue

However, GIP also influences lipid metabolism and energy storage, particularly in adipose tissue, where it can promote fat storage under certain conditions

Tu Q, Wang JF, Xie HQ, et al

Likewise, subcutaneous dulaglutide injection (180 g/kg/twice per week) to EAE mice attenuated the clinical manifestations and histopathological outcomes (lymphocyte infiltration, vacuolar degeneration, and neuronal demyelination), as well as decreased incidences of encephalitogenic Th1/Th17 cells and Th1 granulocyte-macrophage-colony-stimulating factor expression in the CNS (Chiou et al., 2019)